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【多选题】
How does blood glucose regulate insulin secretion by pancreatic β cells?A.
When blood glucose rises, GLUT2 transporters carry glucose into the β cells, where it is immediately converted to glucose 6-phosphate by glucokinase and enters glycolysis.
B.
With the higher rate of glucose catabolism, 2 [ATP] increases, causing the closing of ATP-gated K + channels in the plasma membrane. Reduced efflux of K + depolarizes the membrane. Membrane depolarization opens voltage-gated Ca 2+ channels, and the resulting increase in cytosolic [Ca 2+ ] triggers the release of insulin by exocytosis.
C.
The brain integrates inputs on energy supply and demand, and signals from the parasympathetic and sympathetic nervous systems also affect (stimulate and inhibit, respectively) insulin release.
D.
A simple feedback loop limits hormone release: insulin lowers blood glucose by stimulating glucose uptake by the tissues; the reduced blood glucose is detected by the β cell as a diminished flux through the glucokinase reaction; this slows or stops the release of insulin. This feedback regulation holds blood glucose concentration nearly constant despite large fluctuations in dietary intake.
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【单选题】根据《安全生产许可证条例》规定，安全生产许可证的有效期为（）年。施工企业在安全生产许可证的有效期内未发生死亡事故的，经原发证机关同意，安全生产许可证的有效期可以延期（）年。
A.
2，3
B.
3，2
C.
3，3
D.
2，2
【简答题】安全生产许可证的有效期为 年。安全生产许可证有效期满需要延期的,企业应当于期满前 个月向原安全生产许可证颁发管理机关办理延期手续。
【单选题】When the O 2 concentration is low, as in the peripheral tissues, H + is bound by hemoglobin and O 2 is _________.
A.
released
B.
retained
C.
bound
D.
split
【简答题】At the temperature of the human body, 37℃, the value of is 2.4×10 -14 . Calculate the concentration of H + and OH - , pH and pOH in pure water. What is the relation between pH, pOH, and at this temper...
【判断题】4某旅行社导游李某带团游览一处地势险峻的景点时,众人争相拍照,李某未提示注意安全,该团游客崔某不慎将唐某撞下陡坡摔伤。崔某应当对唐某承担赔偿责任 ()
A.
正确
B.
错误
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