Rotenone, an inhibitor of NADH dehydrogenase, was originally used for fishing. When it was sprinkled on a lake, fish would absorb it through their gills and die. Until recently, it was used in the United States as an organic pesticide and was recommended for tomato plants. It was considered nontoxic to mammals and birds, neither of which can readily absorb it. What effect would rotenone have on ATP production by heart mitochondria, if it could be absorbed?
A.
There would be no reduction in ATP production.
B.
There would be a 95% reduction in ATP production.
C.
There would be a 10% reduction in ATP production.
D.
There would be a 50% reduction in ATP production.
E.
There would be a 50% increase in ATP production.