Which of the following statements about germline gene therapy (GGT) are correct?
A.
GGT involves the introduction of new genetic material into either germ cells (sperm or oocytes) or into zygotes in vitro prior to fertilization or implantation.
B.
In GGT, germ cells (sperm or egg cells) are modified by the introduction of functional genes into their genomes.
C.
Modifying a germ cell causes all the organism's cells to contain the modified gene. The change is therefore heritable and passed on to later generations.
D.
Australia, Canada, Germany, Israel, Switzerland, and the Netherlands prohibit GGT for application in human beings, for technical and ethical reasons, including insufficient knowledge about possible risks to future generations and higher risks versus somatic cell gene therapy (SCGT).