I. life expectancy --born in (1) _____: over the age of 48 --dip there for the 1918 flu. --born in 2010: (2) ______ II. diseases and medicine a. Gap--diseases we now know the exact molecular basis: about (3) _____ vs. diseases now have treatments available: Only about (4) _____ b. What we think: fundamental information to application: a (5) _____ vs. reality: (6) _____ shiny bridge a swimmer, a rowboat , a sailboat ,a tugboat if you're lucky, somebody gets across. III. Why so hard Drug: A small molecule, a few atoms all in a (7) _____ determine whether to hit its target. Process to develop a drug: start out with thousands of compounds weed down through various steps run a clinical trial (8) _____ after you started, you will get one approval. Cost (9) ______ for that one success.