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How does nonhomologous end joining (NHEJ) repair DNA double-strand breaks in eukaryotes?A.
The reaction is initiated at the broken ends of a double-strand break by the binding of a heterodimer consisting of the proteins Ku70 and Ku80. The Ku proteins are conserved in almost all eukaryotes and act as a kind of molecular scaffold to assemble the other protein components.
B.
Ku70-Ku80 interacts with another protein complex containing a protein kinase called DNA-PKcs and a nuclease known as Artemis. Once the complex is assembled, the two broken DNA ends are synapsed (held together). DNA-PKcs autophosphorylates in several locations and also phosphorylates Artemis.
C.
Artemis, when phosphorylated, acquires an endonuclease function that can remove 5′ or 3′ single-stranded extensions or hairpins that might be present at the ends. The DNA ends are then separated with the aid of a helicase, and strands from the two different ends are annealed at locations where short regions of complementarity are encountered.
D.
Artemis cleaves any unpaired DNA segments that are created. Small DNA gaps are filled by a DNA polymerase, Pol μ or Pol λ. Finally, the nicks are sealed by a protein complex consisting of XRCC4 (X-ray cross complementation group), XLF (XRCC4-like factor), and DNA ligase IV.
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【简答题】一质点,以π m/ s 的匀速率作半径为 5 m 的圆周运动,则该质点在 5s 内,位移的大小和路程分别是 m 和 m 。
【简答题】下列疾病中出现的胸水不是渗出液的是（ ）
【简答题】一质点,以πm/s的匀速率作半径为5m的圆周运动,则该质点在5s内,位移的大小是 ,经过的路程 。
【单选题】患者女,45岁。小学文化。刚刚知晓自己被诊断为原发性支气管肺癌,询问护士:“我是不是活不了多久了?”针对该患者的心理护理,错误的是( )
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耐心倾听患者的诉说
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C.
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一一康有为《应诏统筹全局折》
材料二
中国数千年来都是君主，这种，不是平等自由的国民所堪受的，要去这一，不是专靠民族革命可以成功……我们推倒清政府，从驱除满人那...
【简答题】泰国实行的为()
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