The tendency to develop depression is inherited and may run in (1)_____ Depression may be caused by changes or imbalances in (2)______called neurotransmitters, which transmit (3)_______in the brain. Antidepressant medications relieve (4)______of depression. Low (5)______and self-defeating thinking are connected with depression. Sufferers who make corrections to their (6)______can show improved (7)______and self-esteem. Events like the death of a parent, the (8)______of the parents, neglect, chronic illness, and severe (9)_______can increase the likelihood of depression. Job loss, (10)_______, long periods of unemployment, the loss of a spouse or other family member, or long-term (11)_____ may trigger depression. This causes increased (12)_______for those who live with them.