The characteristics of heme synthesis are
A.
Heme synthesis is affected by kidney and brain diseases
B.
Heme is synthesized from succinyl-CoA, glycine and Fe 2+
C.
ALA synthase is the key enzyme for heme synthesis .
D.
Heme is synthesized mainly in bone marrow and liver .
E.
The initial reaction and the last three steps in the formation of porphyrins occur in mitochondria