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How are enzyme-coupled receptors activated?A.
To do its job as a signal transducer, an enzyme-coupled receptor has to switch on the enzyme activity of its intracellular domain (or of an associated enzyme) when an external signal molecule binds to its extracellular domain.
B.
Unlike GPCRs, enzyme-coupled receptor proteins usually have only one transmembrane segment, which spans the lipid bilayer as a single α helix. Because a single α helix is poorly suited to transmit a conformational change across the bilayer, enzyme-coupled receptors have a different strategy for transducing the extracellular signal.
C.
In many cases, the binding of an extracellular signal molecule causes two receptor molecules to come together in the plasma membrane, forming a dimer. This pairing brings the two intracellular tails of the receptors together and activates their kinase domains, such that each receptor tail phosphorylates the other.
D.
In the case of RTKs, the phosphorylations occur on specific tyrosines.
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【简答题】使单片机复位的方法有几种?复位后机器的初始状态如何?
【多选题】对领导科学的研究对象较为全面的表述应包括( )。
A.
领导活动的特点
B.
领导活动的规律
C.
领导的本身
D.
人类的一切社会活动
E.
领导的各个要素相互结合、相互作用的规律
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