压片机增加预压装置

缩短药片受压时间

使压片机车速加快

在处方中大量使用淀粉

加入润滑剂改善

Many of the proteins that enter the ER lumen or ER membrane are converted to glycoproteins in the ER by the covalent attachment of short, branched oligosaccharide side chains composed of multiple sugars.

This process of glycosylation is carried out by glycosylating enzymes present in the ER but not in the cytosol. Very few proteins in the cytosol are glycosylated, and those that are have only a single sugar attached to them.

The oligosaccharides on proteins can serve various functions. They can protect a protein from degradation, hold it in the ER until it is properly folded, or help guide it to the appropriate organelle by serving as a transport signal for packaging the protein into appropriate transport vesicles.

When displayed on the cell surface, oligosaccharides form part of the cell’s outer carbohydrate layer or glycocalyx and can function in the recognition of one cell by another.

压片机增加预压装置

缩短片剂受压时间

使压片机车速加快

在处方中大量使用淀粉

加入润滑剂改善

收入来源

成本机构

融资筹划

资源投入

物流管理模块

财务管理模块

主生产计划

产品结构与物料清单BOM

库存信息

①③④

①②③

②③④

①②④

收入来源

成本机构

融资规筹划

资源投入

In the ER, individual sugars are not added one-by-one to the protein to create an oligosaccharide side chain. Instead, a preformed, branched oligosaccharide containing a total of 14 sugars is attached en bloc to all proteins that carry the appropriate site for glycosylation.

The oligosaccharide is originally attached to a specialized lipid, called dolichol, in the ER membrane; it is then transferred to the amino (NH 2 ) group of an asparagine side chain on the protein, immediately after a target asparagine emerges in the ER lumen during protein translocation. Asparagines that are glycosylated are always present in the tripeptide sequences asparagine-X-serine or asparagine-X-threonine, where X can be almost any amino acid.

The addition takes place in a single enzymatic step that is catalyzed by a membrane-bound enzyme (an oligosaccharyl transferase) that has its active site exposed on the lumenal side of the ER membrane— which explains why cytosolic proteins are not glycosylated in this way.

A simple sequence of three amino acids, of which the target asparagine is one, defines which sites in a protein receive the oligosaccharide. Oligosaccharide side chains linked to an asparagine NH 2 group in a protein are said to be N-linked and this is by far the most common type of linkage found on glycoproteins.

压片机增加预压装置

缩短药片受压时间

使压片机车速加快

在处方中大量使用淀粉

压片机增加顶压装置

缩短压片受压时间

使压片机车速加快

在处方中大量使用淀粉

加入润滑剂改善